Nanostructured Interfaces and Materials Science Group
Frank Caruso delivers QUT public lecture on nanobiomedicine
Prof Frank Caruso delivered an invited public lecture on 20 May 2016 as part of Queensland University of Technology (QUT)'s Institute for Future Environments (IFE) Grand Challenge Lecture Series held in Brisbane, Australia. The presentation was entitled "Targeting Nanotechnology at Biomedicine: Engineering Particles for Nanomedicine Applications" and focused on current NIMS research on the development of engineered particles for cardiovascular disease, tumour targeting, HIV, and drug delivery to the inner ear. Various assembly strategies to generate multifunctional and responsive particles that target, stimulate or distort cells for therapeutic delivery were also discussed.
Chinese government award for NIMS postgrad
NIMS postgrad Qiong (Ada) Dai was awarded the 2015 Chinese Government Award for Outstanding Self-Financed Students Abroad by the China Scholarship Council (CSC). The award was established by the Chinese government in 2003 and is based on academic merit to encourage self-financed international Chinese students achieve first-class results during their studies; only 500 are granted each year worldwide. She is currently researching the intracellular dynamics of nanoengineered materials.
The photo at right shows Qiong Dai (right) with Mr Yumin Song (left), Consul-General at the Consulate-General of the People's Republic of China in Melbourne, where the ceremony was held in April.
JDRF grant awarded to Monash-NIMS collaboration on insulin development
A collaboration with Monash University’s Australian Centre for Blood Diseases (ACBD) has been awarded a grant from the JDRF to support the development of a revolutionary type of insulin. The grant will provide funding to four research projects taking different approaches to developing glucose responsive insulin (GRIs) therapies for treatment of insulin-dependent diabetes. Dr Christoph Hagemeyer (ACBD research group leader) will work in collaboration with Dr Frank Caruso (UniMelb) and Baker IDI’s Dr Jonathan Shaw, Dr Mark Copper and Dr Terri Allen to develop glucose-sensing nanoparticles.
NIMS article on targeted vaccine delivery judged as "Hot Paper"
A recent research paper on targeted vaccine and therapeutic delivery from the NIMS group and international collaborators has been rated as a "Hot Paper" by the Wiley journal, Angewandte Chemie (International Edition). The peer-reviewed article describes how PEGylation is shown to be a key design parameter for improved lymph node delivery of hydrogel nanoparticles incorporating vaccines and therapeutics. Hot Papers are chosen by the journal’s editors for their importance in a rapidly evolving field of high current interest.
NIMS postdoc receives most significant CBNS publication award
At the 1st Centre for Bio-Nano Science Annual Workshop, staged by the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CBNS), NIMS postdoc Dr Jiwei Cui received the award for the most significant CBNS publication of 2015. This was for his paper “Engineering Poly(ethylene glycol) Particles for Improved Biodistribution”, published in ACS Nano. This award was assessed by the CBNS Chief Investigators (CIs) from a shortlist of nominated papers. The judging criteria was: quality and importance of the research; impact of the journal; involvement of multiple CIs, indicating collaboration across the CBNS; and that a CBNS researcher is the lead author of the paper. The photo above right shows (l-r) Dr Jiwei Cui receiving the award from Prof Tom Davis (CBNS Director, Monash University) alongside joint first author Dr Rob De Rose (the University of Melbourne).
NIMS participation at CBNS bio-nano workshop
NIMS group leader Prof Frank Caruso plus six NIMS postdocs and postgrads attended the first annual workshop of the multi-institutional ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CBNS) held in Lorne, Victoria, Australia. Prof Caruso is also Deputy Director of the Centre and was joined by Marc Riemer, Centre Node Coordinator (The University of Melbourne). Covering researchers from five premier Australian universities, the CBNS brings together a diverse of expertise, spanning chemistry and chemical engineering, drug development and pharmaceutical science, cell biology, cellular and biomedical imaging, diagnostics, systems biology, and social theory. The workshop facilitated strong interaction between researchers with groundwork set for further collaborations.
The photo below shows (left-right) Dr Nadja Bertleff-Zieschang, Matt Faria, Dr Jiwei Cui, Danzi Song, Mattias Björnmalm and Prof Caruso at the workshop venue (absent: Dr Christina Cortez-Jugo).
Frank Caruso participates in DAAD German-Australian network workshop
Prof. Frank Caruso delivered a presentation titled “Designing Particles for Biological Interactions” at the first workshop of the DAAD-sponsored German-Australian network (Bayreuth – Melbourne Colloid/Polymer-Network), a collaborative venture between the University of Bayreuth, Leibniz Institute for New Materials and Leibniz Institute for Solid State and Materials Research Dresden (Germany), and the University of Melbourne, Monash University and CSIRO (Australia).
Frank Caruso delivers Professor J.W. McBain Memorial Lecture
Prof Frank Caruso delivered the 13th Professor J.W. McBain Memorial Lecture in Pune, India, in November for the Council of Scientific and Industrial Research (CSIR)-National Chemical Laboratory. His presentation was titled "Advanced Particle Design for Therapeutic Delivery by Interfacing Materials Science and Biology".
Cutting edge NIMS research spotlighted on cover of ACS Macro Letters
NIMS research has been featured on the front cover of ACS Macro Letters. This peer-reviewed paper describes the NIMS group’s research on engineering polymer-coated silica particles and investigating the influence of protein coronas derived from various sources. This study shows how protein coronas can both facilitate and impede particles’ targeting ability to cancer cells. The data highlighted the importance of using multicomponent biologically relevant sources of protein coronas (such as human serum or human plasma), rather than a single model protein (e.g., albumin).
NIMS collaborative research helps with crime-scene investigations
Recent international collaborative research between NIMS researchers, the CSIRO (Australia, including two NIMS alumni) and ICN2 (Spain) has garnered attention in the news and online for its relevance to crime-scene investigations and biomedical applications. The research, published in the Wiley journal Advanced Materials, demonstrates how metal–organic frameworks (MOFs) can be replicated in a biomimetic fashion from protein patterns. This technique can be used to generate bendable, fluorescent MOF patterns with micrometer resolution. These MOF patterns can be grown from fingerprint residue, such as proteins, fatty acids, salts and pectines, and make them glow.
This research paper was also later featured on the journal's cover.
Frank Caruso appointed Melbourne Laureate Professor
The University of Melbourne has appointed Prof Frank Caruso a Melbourne Laureate Professor for demonstrating exceptional distinction and performance as an eminent scholar. The five-year appointment as a Melbourne Laureate Professor represents a significant honour from the University and it will ensure that prominence is given to the work of such professors.
NIMS collaborative research on blood clot-targeting nanocapsules profiled
Recent collaborative research led by Prof Frank Caruso (NIMS) and Prof Christoph Hagemeyer (Baker IDI Heart and Diabetes Institute) has been widely profiled online (including ABC News, Sydney Morning Herald, International Business Times, Nanowerk, phys.org, etc), particularly in the medical field (including Gizmag, Medical News Today, Doctors Health Press, etc). Published in the Wiley journal, Advanced Materials, the research reports on the generation of a nanocapsule that contains a blood clot-busting drug. The drug-loaded nanocapsule is coated with an antibody that specifically targets activated platelets, the cells that form blood clots. It effectively hijacks the blood clotting system to initiate the removal of the blockage in the blood vessel. This targeted drug can potentially offer a safer alternative with fewer side effects for people suffering a heart attack or stroke. This life saving treatment could be administered by paramedics in emergency situations without the need for specialised equipment as is currently the case.
Latest NIMS research profiled in Stories of Australian Science 2015
The latest NIMS research headed by Prof Frank Caruso on biologically friendly drug delivery vehicles has been showcased in Stories of Australian Science 2015, published by Science in Public. This publication (also available online) features cutting edge scientific research by Australian scientists.
In all, 15,000 hard copies were sent out globally. The booklets have been distributed at international science events, and passed to academics, science leaders, policy makers, grant organisations, politicians, dignitaries, students and teachers, and the media.
MIT’s Prof Paula Hammond visits NIMS labs
Prof Paula Hammond, David H. Koch Chair Professor of Engineering at Massachusetts Institute of Technology (MIT), USA, visited the NIMS labs and other academics in the Department of Chemical and Biomolecular Engineering at the University of Melbourne. Prof Hammond is an Editor of the ACS journal ACS Nano, whose inaugural issue showcased Prof Caruso’s research on the front cover.
The photo at right shows Prof Paula Hammond (right) with Prof Frank Caruso.
NIMS researchers score presentation awards at nanomedicine conference
Two NIMS researchers received special awards for their excellent presentations at the 6th International Nanomedicine Conference. NIMS postdoc researcher Dr Jiwei Cui and NIMS alumnus Dr Markus Müllner received Honourable Mentions for Oral Presentation by an Early Career Researcher. Dr Cui’s talk was entitled “Biologically Responsive Polymer Particles via Mesoporous Silica Templating for Drug Delivery”. NIMS postgrad Qiong Dai was awarded Best Oral Presentation by a PhD Student at the conference; her presentation was titled “Monoclonal Antibody-Functionalized Multilayered Particles: Targeting Cancer Cells in the Presence of Protein Coronas”. The awards were presented by A/Prof Grainne Moran (Managing Director of the Mark Wainwright Analytical Centre at UNSW – prize sponsor) and Prof Mary O’Kane (NSW Chief Scientist & Engineer).
The conference was organised by the Australian Centre for NanoMedicine and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. Themed “Great Science in a Great Location”, the event was held in Sydney, Australia, from July 6-8 2015. This conference series is described as “the most significant regular nanomedicine conference in the southern hemisphere”.
The photo at top right shows (left-right) A/Prof Moran, Dr Müllner, Dr Cui and Prof O’Kane. The photo at bottom right shows NIMS postgrad Qiong Dai (centre) flanked by A/Prof Moran (left) and Prof O’Kane (right).
Photo credit: Dr Scott Jamieson (UNSW).
Biomacromolecules paper highlighted in Prostate Cell News
A paper collaboration with researchers in Italy and published in the ACS journal Biomacrolecules has garnered online attention. It was highlighted on Prostate Cell News and BioPortfolio. The paper details the engineering of particular particles to deliver therapeutic nucleic acids to prostate cancer cells.
Collaborative paper on membranes makes journal cover and news
A collaborative paper with Prof Frank Caruso has made the cover of the Wiley journal Advanced Materials. The paper reports on the generation of new membranes that will lead to clean water using a more energy efficient method. This new technology utilises layer-by-layer polymer assembly and the membrane materials are chlorine-resistant, thereby reducing the number of processing steps.
This paper was also profiled in March by ScienceDaily.com, a website focusing on current, prominent research. The research has also been cited on phys.org, Chemical Processing, Water Desalination Report, Chemical Engineering, WaterWorld, and elsewhere.
NIMS postdoc receives Academic Star award
NIMS Research Fellow Dr Biao Kong has received the Chinese Government award of Academic Star in Victoria for 2014. This accolade recognises the most academically outstanding Chinese scholar or student studying overseas; only one is granted each year for Victoria. His current research focuses on high-performance porous metal-polyphenol-frameworks for applications in bioimaging, biosensing, bioenergy and biocatalysis, and he has already published over 30 papers in academic journals.
The photo at right shows Dr Biao Kong (left) with Mr Zhiyong Yang (right), Consul-Officer of the Consulate-General of the People's Republic of China in Melbourne.
NIMS postgrad scores best student presenter at microfluidics symposium
NIMS postgrad Mattias Björnmalm was awarded the “Best Student Presenter” at the 6th Australia and New Zealand Nano- Microfluidics Symposium (ANZNMF) held in Melbourne, Australia in April 2015. His presentation was titled "Microfluidic blood capillary model with super-soft hydrogel particles".
The photo at right shows two of the conference chairs, Prof Stephen Haswell (left) and Dr Sean Langelier (right) congratulating Mattias Björnmalm (centre).
NIMS postgrad wins prestigious Chinese government award
NIMS postgrad Junling Guo has been granted the 2014 Chinese Government Award for Outstanding Self-Financed Students Abroad by the China Scholarship Council (CSC). This award was founded by the Chinese government in 2003 to reward the academic excellence of self-financed Chinese students studying overseas with only 500 granted each year worldwide. He currently researches polyphenol-inspired nanomaterials for applications in drug delivery, bioimaging and catalysis.
The photo at right shows Junling Guo (left) with Mr Yumin Song (right), Consul-General at the Consulate-General of the People's Republic of China in Melbourne, where the ceremony was held in April.
Collaborative polymer capsules paper featured on cover of Advanced Science
A collaborative paper published in the Wiley journal Advanced Science details research into the cargo loading of functional polymer capsules. This has been featured on the journal’s cover and showcases a collaboration between the NIMS group, the Baker IDI Heart and Diabetes Institute and Ghent University. A variety of diverse functional and therapeutic cargo can be loaded into polymer capsules with 15 types of cargo investigated, yielding a toolbox with effectively 500+ variations. This process uses no harsh reagents and can take less than 30 minutes to prepare, load, coat and form the hollow capsules. As such, this technique may well play a crucial role across scientific studies in numerous fields. It should be noted that Advanced Science is an open access journal.
This research was also highlighted on Wiley’s Materials Views website in March.
Collaborative CAP paper featured on cover of Chemical Communications
The latest collaborative paper on the continuous assembly of polymers (CAP) by Prof Frank Caruso and Prof Greg Qiao’s Polymer Science Group, also based at the University of Melbourne, has been featured on the cover of the RSC journal, Chemical Communications. The research paper describes the preparation of surface-confined ultrathin polyrotaxane (PRX)-based films with tuneable composition, surface topology and swelling characteristics using solid-state CAP. It was found that the PRX-based films supported cell attachment, and their degradation in biological media could be tuned. This study provides a versatile nano-coating technology with potential applications in biomedicine, including tissue engineering and medical devices.
NIMS paper makes top 20 list of 2014’s most accessed Soft Matter papers
The RSC journal Soft Matter has ranked its top 20 most accessed papers published in 2014. This list includes a NIMS paper on the nanoscale engineering of low-fouling surfaces. The research may lead to the design of low-fouling surfaces using a coating technique that can be applied to various applications.
Caruso paper 3rd most cited in Chemistry—A European Journal
The Wiley peer-reviewed journal, Chemistry—A European Journal, celebrated its 20th year at the end of 2014. A 2000 communication paper by Frank Caruso made the list of the journal’s top 20 most-cited papers in third spot. The paper describes the fabrication of hollow composite capsules using various colloidal particles as templates. The paper is now open access.
NIMS hydrogel particle research spotlighted on cover of Advanced Materials
A NIMS research paper on super-soft hydrogel particles has been featured on the cover of the Wiley journal Advanced Materials. The research describes how the elasticity of the particles can be tuned to mimic the deformability behaviour of human red blood cells in a microfluidic blood-capillary model. These results provide a new platform for the design and development of soft hydrogel particles for investigating bio-nano interactions.
Frank Caruso's collaborative research scores 2 frontispieces
Two of Prof Frank Caruso's collaborative research outcomes with international researchers have been recognised with frontispieces in their respective journals.
The collaboration with Korean researchers published in Angewandte Chemie (Int. Ed.) focused on artificial single-cell encapsulation for cytoprotection.
Another collaboration included researchers from the Bionics Institute, Australia, and Fudan University in China; this was published in Small and covered mesoporous silica supraparticles that could be implanted into the cochlea to prevent the progressive loss of auditory neurons.
NIMS postgrad wins best tutor award
Yi (David) Ju shared a feedback-based Best Tutor award for semester 2, 2014 in the Department of Chemical and Biomolecular Engineering (the NIMS host department) at the University of Melbourne.
ARC LIEF grant awarded for NIMS-hosted cytometer
The Australian Research Council (ARC) has awarded a 2015 LIEF grant for Cytometer by Time of Flight (CyTOF), which will be housed in the NIMS labs. This acquisition will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics.
Nobel Prize-winning microscopy techniques used in NIMS labs
The Nobel Prize in Chemistry 2014 was awarded jointly to Eric Betzig, Stefan Hell and William Moerner for the development of super-resolved fluorescence microscopy. This technology is utilised in the NIMS labs, which house the Nikon N-STORM super-resolution fluorescence microscope and utilises the principles behind single molecule imaging. These super-resolution techniques are used for a wide range of applications, from tracking the behaviour of nanoparticles inside cells, to characterising the aggregation of proteins at the nano-scale and probing the interaction of molecules inside cells.
This was later spotlighted by the University of Melbourne in The Melbourne Engineer e-bulletin.
The photo at right shows Ben Hibbs, Platform Support Officer at the Materials Characterisation and Fabrication Platform, with the N-STORM microscope.
NIMS article among the most read in Biomacromolecules journal for 2014
A recent NIMS research paper published in Biomacromolecules has been assessed as one of the Most Read Articles for the period January - June 2014. The article focuses on thermodynamically assembled core–shell nanocarriers that consist of noncovalent polymers, i.e., polyrotaxanes (PRXs). These are potential candidates for drug delivery applications due to their submicrometer size and drug-loading ability.
NIMS postgrad scores overseas study scholarship
NIMS postgraduate researcher, Sylvia Gunawan, has been awarded an Overseas Research Experience Scholarship (ORES) from the University of Melbourne. This helps fund travel and living expenses for her research visit to the Irvine group in the Immunoengineering Lab at the Department of Biological Engineering/Department of Materials Science of Engineering, Massachusetts Institute of Technology (MIT), USA. Her research will focus on cancer immunotherapy.
NIMS researcher awarded Dyason Fellowship
NIMS postdoctoral researcher, Dr Yan Yan, was awarded a Dyason Fellowship to undertake a project analysing nanoparticles. This will form part of a collaboration with the Centre for BioNano Interactions (CBNI) at University College Dublin, Ireland. Dyason Fellowships have been established to advance education by fostering international academic collaborations.
ARC Centre of Excellence launches
The ARC Centre of Excellence in Convergent Bio-Nano Science and Technology was officially launched on 28 August 2014 and included various notable academics and dignitaries. The ARC-funded Centre is a national innovator in bio-nano sciences and an incubator of the expertise and technological excellence required to develop next generation bio-responsive nanomaterials. Prof Frank Caruso is Deputy Director of the Centre, which is hosted at Monash University with Centre nodes at other institutions, including the University of Melbourne.
The photo above right depicts (l-r) Prof Frank Caruso (Centre Deputy Director) with Prof Aidan Byrne (ARC Chief Executive Officer) and Prof Tom Davis (Centre Director) at the launch.
Frank Caruso awarded 2014 Victoria Prize
Prof Frank Caruso was awarded the 2014 Victoria Prize for Science and Innovation in the category of physical sciences by the state government’s Innovation Minister, the Hon Louise Asher. The award recognises the commitment and achievements of Prof Caruso’s internationally recognised research. The Victoria Prize is managed by the Victorian Endowment for Science, Knowledge and Innovation (veski) and funded by the Victorian Government.
The photo at right shows (l-r) Louise Asher with Prof Frank Caruso.
A promotional video has been posted on YouTube where Prof Caruso elaborates on his research and future directions of scientific study.
New Future Fellow joins NIMS research
Dr Francesca Cavalieri, formerly of the University of Rome Tor Vergata, Italy, has been awarded an ARC Future Fellowship to undertake research at the University of Melbourne with a focus on developing new nanomaterials to enhance targeted miRNA delivery in cancer therapy. Dr Cavalieri has previously been a visitor and collaborator in the NIMS research group. The Future Fellowships scheme promotes research in areas of critical national importance by supporting outstanding mid-career researchers to conduct their research in Australia.
Frank Caruso named Thomson Reuters Highly Cited Researcher
Thomson Reuters has announced its Highly Cited Researchers for 2014, listing the world's leading thinkers in science and engineering whose research papers rank among the top 1% most cited for their subject field and publication year, earning them the mark of exceptional impact. Prof Frank Caruso was listed as the top Australian in the Materials Science category. As a member of the Highly Cited Researcher list, Prof Caruso is also included in Thomson Reuters' 2014 World's Most Influential Scientific Minds.
Collaborative CAP paper scores front cover of Chemical Science
A recent research article on the continuous assembly of polymers (CAP) via solid phase reactions has garnered the front cover of Chemical Science, a peer-reviewed journal (2013 impact factor 8.6) published by the Royal Society of Chemistry. The paper reports on an effective method for the fabrication of smooth, surface confined, cross-linked nanostructured films, and is part of a collaborative project between Prof Frank Caruso and Prof Greg Qiao’s Polymer Science Group, also at the University of Melbourne.
2 NIMS postgrads win travel scholarships
Two NIMS postgraduate students, Mattias Björnmalm and Sylvia Gunawan, have been awarded 2014 Clive Pratt Scholarships from the University of Melbourne. These scholarships go towards travel costs for research visits.
NIMS article on the multifunctional microcapsules judged as "Hot Paper"
A recent research paper on multifunctional microcapsules from the NIMS group and collaborators has been rated as a “Hot Paper” by the Wiley journal, Angewandte Chemie (International Edition). The peer-reviewed article describes how a single organic ligand, tannic acid, can be coordinated to 18 different metals to form capsules made of metal-phenolic networks (MPNs). The capsule properties depend on the type and number of metal ions; as such, they can have various applications, including drug delivery, multicoloured fluorescence labelling of biological samples, flexible colour displays, contrast agents and catalysis. Hot Papers are chosen by the journal’s editors for their importance in a rapidly evolving field of high current interest.
This article’s impact was also considered so strong as to warrant that issue's front cover.
NIMS research featured as cover article in Advanced Materials
A NIMS research paper on biomedical applications has been featured on the back cover of the Wiley journal, Advanced Materials. The peer-reviewed paper contributes to research on smart delivery systems with inbuilt biological triggers which are emerging for advanced therapeutic delivery applications. This Communication reports the synthesis of crosslinker-free, layer-by-layer (LbL) capsules that utilise cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells.
NIMS contributes to 25th anniversary issue of Chemistry of Materials journal
Prof Frank Caruso and the NIMS research group were invited to submit a review for inclusion in the Special Issue on the 25th anniversary of the prominent, peer-reviewed .journal, Chemistry of Materials. Their review is titled "Assembly of Layer-by-Layer Particles and Their Interactions with Biological Systems,” and it provides an overview of developments in the engineering of multilayered polymer particles, also describing recent progress in their utilization in biomedical applications.
Prof Caruso is an editor of the journal, which has an impressive 2013 impact factor of 8.535.
Personal Assistant to Prof Frank Caruso
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