Nanostructured Interfaces and Materials Science Group
NIMS hydrogel particle research spotlighted on cover of Advanced Materials
A NIMS research paper on super-soft hydrogel particles has been featured on the cover of the Wiley journal Advanced Materials. The research describes how the elasticity of the particles can be tuned to mimic the deformability behaviour of human red blood cells in a microfluidic blood-capillary model. These results provide a new platform for the design and development of soft hydrogel particles for investigating bio-nano interactions.
Frank Caruso's collaborative research scores 2 frontispieces
Two of Prof Frank Caruso's collaborative research outcomes with international researchers have been recognised with frontispieces in their respective journals.
The collaboration with Korean researchers published in Angewandte Chemie (Int. Ed.) focused on artificial single-cell encapsulation for cytoprotection.
Another collaboration involved researchers from the Bionics Institute, Australia, and Fudan University in China; this was published in Small and covered mesoporous silica supraparticles that could be implanted into the cochlea to prevent the progressive loss of auditory neurons.
ARC LIEF grant awarded for NIMS-hosted cytometer
The Australian Research Council (ARC) has awarded a 2015 LIEF grant for Cytometer by Time of Flight (CyTOF), which will be housed in the NIMS labs. This acquisition will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics.
Nobel Prize-winning microscopy techniques used in NIMS labs
The Nobel Prize in Chemistry 2014 was awarded jointly to Eric Betzig, Stefan Hell and William Moerner for the development of super-resolved fluorescence microscopy. This technology is utilised in the NIMS labs, which house the Nikon N-STORM super-resolution fluorescence microscope and utilises the principles behind single molecule imaging. These super-resolution techniques are used for a wide range of applications, from tracking the behaviour of nanoparticles inside cells, to characterising the aggregation of proteins at the nano-scale and probing the interaction of molecules inside cells.
The photo at right shows Ben Hibbs, Platform Support Officer at the Materials Characterisation and Fabrication Platform, with the N-STORM microscope.
NIMS article among the most read in Biomacromolecules journal for 2014
A recent NIMS research paper published in Biomacromolecules has been assessed as one of the Most Read Articles for the period January - June 2014. The article focuses on thermodynamically assembled core–shell nanocarriers that consist of noncovalent polymers, i.e., polyrotaxanes (PRXs). These are potential candidates for drug delivery applications due to their submicrometer size and drug-loading ability.
NIMS postgrad scores overseas study scholarship
NIMS postgraduate researcher, Sylvia Gunawan, has been awarded an Overseas Research Experience Scholarship (ORES) from The University of Melbourne. This helps fund travel and living expenses for her research visit to the Irvine group in the Immunoengineering Lab at the Department of Biological Engineering/Department of Materials Science of Engineering, Massachusetts Institute of Technology (MIT). Her research will focus on cancer immunotherapy.
NIMS researcher awarded Dyason Fellowship
NIMS postdoctoral researcher, Dr Yan Yan, was awarded a Dyason Fellowship to undertake a project analysing nanoparticles. This will form part of a collaboration with the Centre for BioNano Interactions (CBNI) at University College Dublin. Dyason Fellowships have been established to advance education by fostering international academic collaborations.
ARC Centre of Excellence launches
The ARC Centre of Excellence in Convergent Bio-Nano Science and Technology was officially launched on 28 August 2014 and included various notable academics and dignitaries. The ARC-funded Centre is a national innovator in bio-nano sciences and an incubator of the expertise and technological excellence required to develop next generation bio-responsive nanomaterials. Prof Frank Caruso is Deputy Director of the Centre, which is hosted at Monash University with Centre nodes at other institutions, including The University of Melbourne.
The photo above right depicts (l-r) Prof Frank Caruso (Centre Deputy Director) with Prof Aidan Byrne (ARC Chief Executive Officer) and Prof Tom Davis (Centre Director) at the launch.
Frank Caruso awarded 2014 Victoria Prize
Prof Frank Caruso was awarded the 2014 Victoria Prize for Science and Innovation in the category of physical sciences by the state government’s Innovation Minister, the Hon Louise Asher. The award recognises the commitment and achievements of Prof Caruso’s internationally recognised research. The Victoria Prize is managed by the Victorian Endowment for Science, Knowledge and Innovation (veski) and funded by the Victorian Government.
The photo at right shows (l-r) Louise Asher with Prof Frank Caruso.
New Future Fellow joins NIMS research
Dr Francesca Cavalieri, formerly of the University of Rome Tor Vergata, Italy, has been awarded an ARC Future Fellowship to undertake research at The University of Melbourne with a focus on developing new nanomaterials to enhance targeted miRNA delivery in cancer therapy. Dr Cavalieri has previously been a visitor and collaborator in the NIMS research group. The Future Fellowships scheme promotes research in areas of critical national importance by supporting outstanding mid-career researchers to conduct their research in Australia.
Frank Caruso named Thomson Reuters Highly Cited Researcher
Thomson Reuters has announced its Highly Cited Researchers for 2014, listing the world's leading thinkers in science and engineering whose research papers rank among the top 1% most cited for their subject field and publication year, earning them the mark of exceptional impact. Prof Frank Caruso was listed as the top Australian in the Materials Science category. As a member of the Highly Cited Researcher list, Prof Caruso is also included in Thomson Reuters' 2014 World's Most Influential Scientific Minds.
Collaborative CAP paper scores front cover of Chemical Science
A recent research article on the continuous assembly of polymers (CAP) via solid phase reactions has garnered the front cover of Chemical Science, a peer-reviewed journal (2013 impact factor 8.6) published by the Royal Society of Chemistry. The paper reports on an effective method for the fabrication of smooth, surface confined, cross-linked nanostructured films, and is part of a collaborative project between Prof Frank Caruso and Prof Greg Qiao’s Polymer Science Group, also at The University of Melbourne.
2 NIMS postgrads win travel scholarships
Two NIMS postgraduate students, Mattias Björnmalm and Sylvia Gunawan, have been awarded 2014 Clive Pratt Scholarships from The University of Melbourne. These scholarships go towards travel costs for research visits.
NIMS article on the multifunctional microcapsules judged as "Hot Paper"
A recent research paper on multifunctional microcapsules from the NIMS group and collaborators has been rated as a “Hot Paper” by the Wiley journal, Angewandte Chemie (International Edition). The peer-reviewed article describes how a single organic ligand, tannic acid, can be coordinated to 18 different metals to form capsules made of metal-phenolic networks (MPNs). The capsule properties depend on the type and number of metal ions; as such, they can have various applications, including drug delivery, multicoloured fluorescence labelling of biological samples, flexible colour displays, contrast agents and catalysis. Hot Papers are chosen by the journal’s editors for their importance in a rapidly evolving field of high current interest.
This article’s impact was also considered so strong as to warrant that issue's front cover.
NIMS research featured as cover article in Advanced Materials
A NIMS research paper on biomedical applications has been featured on the back cover of the Wiley journal, Advanced Materials. The peer-reviewed paper contributes to research on smart delivery systems with inbuilt biological triggers which are emerging for advanced therapeutic delivery applications. This Communication reports the synthesis of crosslinker-free, layer-by-layer (LbL) capsules that utilise cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells.
NIMS contributes to 25th anniversary issue of Chemistry of Materials journal
Prof Frank Caruso and the NIMS research group were invited to submit a review for inclusion in the Special Issue on the 25th anniversary of the prominent, peer-reviewed .journal, Chemistry of Materials. Their review is titled "Assembly of Layer-by-Layer Particles and Their Interactions with Biological Systems,” and it provides an overview of developments in the engineering of multilayered polymer particles, also describing recent progress in their utilization in biomedical applications.
Prof Caruso is an editor of the journal, which has an impressive 2013 impact factor of 8.535.
Frank Caruso named Deputy Director of new ARC Centre of Excellence
Prof Frank Caruso has been named Deputy Director of the new ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. This new Centre of Excellence (CoE) starting in 2014 will be headed by Prof Tom Davis, Monash University, and comprises an international and multidisciplinary team focused on research at the bio-nano interface to design materials that deliver vaccines, drugs and gene therapy agents, and to develop new diagnostic agents and devices. The CoE is expected to be the focus of bio-nano research activity in Australia, fostering collaboration between universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano interface. ARC CoEs are prestigious hubs of expertise through which high-quality researchers maintain and develop Australia's international standing in research areas of national priority.
Frank Caruso reports on binding particles to cells in Nature
Nature News & Views includes a report by Prof Frank Caruso and A/Prof Andrea O'Connor, both from the Department of Chemical and Biomolecular Engineering at The University of Melbourne. They discuss recent research focused on finding a way to control how particles bind to cells, which could lead to opportunities to further biomedical research and applications. The short report in Nature looks at how particles can be designed to deliver payloads of therapeutic drugs and organise cells.
NIMS postgrad scores travel scholarship
NIMS postgraduate James Best is congratulated for being awarded the 2013 Clive Pratt Scholarship from The University of Melbourne. These scholarships go towards travel costs for research visits.
Frank Caruso awarded Eureka Prize for Leadership in Science
Prof Frank Caruso has been awarded the CSIRO Eureka Prize for Leadership in Science for his research leadership and collaborative achievements in the development and application of nanotechnology-enabled materials for biomedical research, such as vaccine and drug delivery or to generate sharper imaging from MRI scans. A short video about his work recognised the Eureka Prize is on YouTube. This has been reported in various news sources, included ABC’s News in Science, The Age, Sydney Morning Herald and Canberra Times newspapers, and The Conversation online news analysis. The Australian Museum Eureka Prizes rank among Australia’s most comprehensive national science and research awards.
The picture at right shows Prof Frank Caruso with his Eureka Prize.
Photo credit: Australian Museum Eureka Prizes and photographer Daniel O’Doherty.
NIMS researchers score Eureka Prize for interdisciplinary research
Prof Frank Caruso and NIMS postdoctoral researcher, Dr Yan Yan, formed part of the collaborative team led by Prof Lloyd Hollenberg awarded the University of New South Wales Eureka Prize for Excellence in Interdisciplinary Scientific Research for their involvement in the Quantum Bio-probes collaboration. This collaboration is the first to measure a single quantum probe in a living biological system using nano-scale diamond sensors that can light up the insides of cells. This work will help researchers see what goes on inside a living cell in unprecedented detail. As with Prof Frank Caruso’s individual award reported above, this has received wide news coverage. The Australian Museum Eureka Prizes rank among Australia’s most comprehensive national science and research awards.
The photo above right shows (l-r) Prof Frank Caruso, Prof Lloyd Hollenberg and Dr Yan Yan.
Photo credit: Australian Museum Eureka Prizes and photographer Daniel O’Doherty.
Frontispiece for collaborative polymer paper
A collaborative research paper has been published with a frontispiece in the Wiley journal, Advanced Materials. The Communication describes how free-standing polypeptide films are formed by a novel cross-linking pathway involving cross-chain terminations of polypeptide chains grown from multifunctional initiators. This fabrication method provides a facile approach towards the formation of stable cross-linked polypeptide capsules with tunable thickness, compositions, and enzymatic degradability. This paper is part of a collaborative project undertaken by Prof Frank Caruso and Prof Greg Qiao’s Polymer Science Group, also at The University of Melbourne.
NIMS research into natural and efficient nanosurfaces featured in Science
Science has published NIMS research into a new strategy to coat microscopic materials, leading to a new-generation particle system with engineered properties. This is expected to underpin advances in the delivery of therapeutics in the areas of cancer, vaccines, cardiovascular disease and neural health. The capsules can be engineered to degrade under different conditions, providing opportunities for the timed release of substances contained inside the capsules, and can be assembled rapidly from naturally occurring materials (minerals and nutrients) with specific physical and chemical properties, making it a versatile platform for various applications. The paper has also been featured on the magazine’s ScienceNews site.
This research has received international attention and has been profiled elsewhere, including a research highlight on drug delivery in the journal Angewandte Chemie, as well as the premier nanotechnology information website nanotechweb.org, the New York Times, ABC’s Science website, which tagged it as "New nano-coating from plant chemical", the prominent science website Phys.org, the biotechnology industry site Biotech Daily, as well as the US-based TopNews website. The American Chemical Society’s Chemical & Engineering News (C&EN) also profiled the research as did The Melbourne Engineer. The broad media coverage includes radio news on science on Triple R and a short interview on current affairs radio 2UE.
NIMS article makes Australian Synchrotron research highlight list
A NIMS article, published in the premier peer-reviewed journal Advanced Materials, was chosen as a key highlight for the Australian Synchrotron’s 2010-2012 Research Highlights report. NIMS researchers investigated a novel method to create versatile and stable biofunctional polymer nanostructures through a highly simplified procedure. Part of this research entailed the use of facilities at the Australian Synchrotron, specifically extended X-ray absorption fine structure (EXAFS) spectroscopy, with the aim of elucidating the driving force behind the non-covalent biopolymer assembly.
NIMS article on the electrophoretic polymer assembly judged as "Hot Paper"
A recent research paper from the NIMS group has been assessed as a “Hot Paper” by the Wiley journal, Angewandte Chemie (International Edition). The peer-reviewed article reveals how multilayered polymer thin films were assembled on particles immobilized in agarose by electrophoresis on the basis of various interactions. Core removal then led to robust capsules with different polymer compositions. This approach enables the versatile and routine assembly of nanometer- and micron-sized capsules and coated particles with very few processing steps. Hot Papers are chosen by that journal’s editors for their importance in a rapidly evolving field of high current interest.
Frank Caruso guest co-editor of journal's special issue on nanocrystals
Prof Frank Caruso was a guest Manuscript Co-Editor for a special issue of the peer-reviewed journal, Chemistry of Materials (volume 25, issue 8), published in April 2013. This issue focused on synthetic and mechanistic advances in nanocrystal growth with particular emphasis given to the control of nanocrystals with regard to morphology, size, phase, and composition, as well research into establishing chemical and crystal-growth pathways, and control of surface and core structure. The journal recently posted another jump in its impact factor (8.238) and citations (74,651), reinforcing its significant impact and leadership in materials chemistry research.
Frank Caruso delivers Bayer Distinguished Lectureship at Texas A&M University
Texas A&M University, USA, honoured Prof Frank Caruso with the Bayer Distinguished Lectureship in which he gave a two-part presentation entitled “Nanoengineering Particles for Therapeutic Delivery: Prospects and Challenges” to academics, students and guests in early April 2013.
Frank Caruso appointed Honorary Research Fellow at Bionics Institute
Prof Frank Caruso has been selected as an eminent clinician in Melbourne and appointed an Honorary Research Fellow at the Bionics Institute, Melbourne, Australia. This will entail contributing to research initiatives, collaborations and grant applications.
New EAB positions for Frank Caruso
Prof Frank Caruso has been appointed to the Editorial Advisory Boards of the prominent American Chemical Society journal, ACS Nano (2012 impact factor of 12.062), and the new journal from the Royal Society of Chemistry, Biomaterials Science. This builds on his other existing EAB positions on high-ranked journals published by Wiley-VCH and Elsevier.
Frank Caruso profiled by Angewandte Chemie journal
Leader of the NIMS group, Prof Frank Caruso, received an author profile in the Wiley journal Angewandte Chemie, which has an impressive impact factor of 13.734 (2012 ranking). Authors are profiled with personal highlights when they have published a significant number of papers in the journal, in this case 10 papers.
CAP paper collaboration featured on front cover of Polymer Chemistry
A collaborative paper by Prof Frank Caruso et al. has been featured on the front cover of the peer-reviewed journal, Polymer Chemistry, published by the Royal Society of Chemistry. The continuous assembly of polymers (CAP), mediated via ring-opening metathesis polymerization (ROMP), is demonstrated in the paper as a simple and versatile method to fabricate tailored nanostructured thin films. This paper forms part of a collaborative project between Prof Frank Caruso and Prof Greg Qiao’s Polymer Science Group, also based at The University of Melbourne.
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